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Highlights from the 14th Annual Meeting of the Oligonucleotide Therapeutics...
Nearly 600 Attendees from Around the Globe Converge in Seattle Four Full Days of Nucleic Acid-Based Therapeutics Talks and Posters by Academics and Companies Jerry Comments on His OTS 2018 Favorites...
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April is Parkinson’s Awareness Month
An Estimated 10 Million People Worldwide Have Parkinson’s Disease (PD) A Cure for PD Has Yet to Be Discovered Short-Interfering RNA (siRNA) Knockdown and mRNA-Based Cell Reprogramming Are Shown to Be...
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In Vivo High-Throughput Screen Finds Lipid Nanoparticles (LNPs) for...
Multiplexed Screening of Hundreds of LNPs Compositions In Vivo Barcodes and Sequencing Identify Cell-Type Tropisms In Vivo CRISPR Gene-Editing in Endothelial Cells Provides Proof-of-Concept 3D...
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Doubling Down on siRNAs in the Brain
Novel “Di-siRNA” Compound Affords Long-Lasting Gene Silencing in the Brain A Single Injection Leads to Gene Silencing for at Least One Month! Cooperativity of Phosphorothioate Linkages is Key for this...
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Anti-Prion Antisense Oligonucleotides (ASOs): A Possible Therapy for...
The Principle of Infectious Prions Led to a Nobel Prize in 1997 ASOs Against Prions Have Been Investigated as a Possible Therapy for CJD Mechanistic Details for Anti-Prion ASOs Continue to Evolve...
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April is Parkinson’s Awareness Month – 2020
10 Million People Worldwide Have Parkinson’s Disease (PD) Currently, There Is Care but No Cure for PD Promising Advances in Nucleic Acids Research May Change This Parkinson’s disease (PD) is a...
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Reversing Parkinson’s Disease with An Antisense Oligonucleotide
10 Million People Worldwide Have Parkinson’s Disease (PD) There is Currently No Cure for PD Treating PD with An Antisense Oligonucleotide is Now Clinically Feasible Parkinson’s disease (PD), a...
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Highlights from the 16th Annual Oligonucleotide Therapeutics Society (OTS)...
Enzymatic Synthesis of Oligonucleotide RNA Demonstrated for the First Time Novel Overhanging Duplex Oligonucleotide Constructs Improve Antisense Efficacy Ligation-Mediated qPCR Enables...
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Feasibility of Antisense Oligonucleotides as DNA Insecticides
As Resistance to Pesticides Emerges, New Alternatives are Needed An Unmodified 11-mer Antisense Oligonucleotide Has Been Used Against Gypsy Moth Larvae Implementation and Extension of This Finding to...
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Focus on 2’-Fluoro RNA Aptamers for Fighting Cancer
RNA Aptamers Enable Cancer-Cell Specific Delivery and/or Detection 2’-Fluoro-Modified RNAs Are Resistant to Degradation by Nucleases Four Novel 2’-Fluoro RNA Aptamers for Fighting Cancer Introduction...
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